Ron Seybold's Viral Times

A story to inject hearts with insight, hope and health

Archive for the ‘Public health’ Category

Government funds hurry-up disease fighters

leave a comment »

The world is so far behind on its supply of anti-bacterial drugs that the US government is paying a major pharma to create and test formulas more quickly. This government aid to pharmaceutical giants like GlaxoSmithKline rolls into full tilt in Viral Times, just some five years from now.

But this year, pressure has mounted for accelerated creation of drugs to fight superbugs — things like MRSA and worse, for which there appears to be no protection. Going to the hospital is a serious decision itself about maintaining health.

From the New York Times:

Government officials, drug companies and medical experts, faced with outbreaks of antibiotic-resistant “superbugs,” are pushing to speed up the approval of new antibiotics, a move that is raising safety concerns among some critics.

The need for new antibiotics is so urgent, supporters of an overhaul say, that lengthy studies involving hundreds or thousands of patients should be waived in favor of directly testing such drugs in very sick patients. Influential lawmakers have said they are prepared to support legislation that allows for faster testing.

The Health and Human Services Department last month announced an agreement under which it will pay $40 million to a major drug maker, GlaxoSmithKline, to help it develop medications to combat antibiotic resistance and biological agents that terrorists might use. Under the plan, the federal government could give the drug company as much as $200 million over the next five years.

“We are facing a huge crisis worldwide not having an antibiotics pipeline,” said Dr. Janet Woodcock, director of the Center for Drug Evaluation and Research at the Food and Drug Administration. “It is bad now, and the infectious disease docs are frantic. But what is worse is the thought of where we will be five to 10 years from now.”

If you play out this trend, two aspects emerge. First, the defense of our populace from disease will make the military defense budgets look small. While you’re unlikely to be attacked by a rogue cell of terrorists, catching a superbug is a genuine possibility. Uncounted billions will be tossed at this threat.

Second, this is only drug defense against bacterial infection we’re seeing in the Times story. Viruses are much more adaptive and evasive. We have fewer successful anti-virals than anti-bacterials. It’s reasonable to imagine that pharmacos, like PharmaCorp in Viral Times, can grow larger than a defense contractor like McDonnell Douglas.

Written by Ron Seybold

July 5, 2013 at 3:47 pm

West Nile Virus on the rise in Texas

leave a comment »

In my home here in Austin, we’re hearing reports about a rising number of infections from the West Nile Virus. The mosquito population here never carried this disease, at least not until this year. Now there’s been seven reported infections in the Austin area, and at least one death statewide. A few people in my family are scared.

What’s notable is that the warnings and reports include the word epidemic. One doctor said he’d never seen an epidemic like this in Texas. He’s relying on a definition of the word that people who’ve seen Contagion may not understand — but it’s not the right term. An epidemic is a series of infections which are high in number across a geographic area. The number of infections, in total, doesn’t create an epidemic. You need a concentrated geographic area.

He may have been using comparative thinking, but seven infections among a Texas population of more than 15 million — anybody who gets a mosquito bite could be infected — well, that’s not a high number. Not high enough for an epidemic. Under one definition, an epidemic has to spread quickly, too. An epidemic is in a concentrated geographic area. We’re hearing our reports about Travis County. But that’s only seven reports.

Our world endured an H1N1 pandemic over the past two years. That’s an infection across vast geographic areas, though not necessarily high in overall numbers. Despite that official UN health organization’s designation, the 2010-11 infections didn’t change the world’s physical contact between persons, or reshape laws about sanitation and disinfection. Or spark a tremendous business sector devoted to protection. That’s the stuff of Viral Times — although the governments of my novel are not responding evenly, or with enough resources.

Written by Ron Seybold

August 8, 2012 at 8:59 am

Climate changes will increase evolution of new flu strains

with one comment

A report from Duke University’s Nicholas School of the Environment says changing climate will affect the likelihood of contracting a new deadly strain of the flu. Never mind the heat — it’s the infection that will get you.

Migratory birds play a central role by giving a virus an additional opportunity to evolve

It’s the shifts between El Nino and La Nina weather that will wreak havoc with the bird migration patterns. Birds, migratory birds in particular, play a central role, by either passing a flu strain directly to humans (as in the case of H1N1) or indirectly via an intermediate host, giving the virus an additional opportunity to evolve.

The El Niño-La Niña oscillations cause significant changes in regional rainfall rates and wind patterns, which in turn affect the migration pattern of birds. And these shifts lead to different groups of of bird species coming into contact with each other in a given region, allowing for new strains of influenza to develop that eventually jump to humans.

In Viral Times, birds are an active transmission agent in the spread of the New Flu and other viruses. The dominant breeds of birds, especially starlings and crows, are among the deadliest of these agents.

The El Niño-Southern Oscillation (ENSO) refers to the state of the tropical Pacific Ocean as it sloshes back and forth, like water in a huge bathtub, west and east between Asia and the Americas. This movement affects temperatures and weather patterns worldwide.

One means to combat the infection might be to reduce use of fossil fuels. But after generations of burning coal and oil, it might be too late to reverse the Nino-Nina bathtub slosh effects. It’s back to our firewall of protection against viruses: natural immunity.

Written by Ron Seybold

May 2, 2012 at 4:44 pm

Pharma titan Pfizer adds natural immunity product

leave a comment »

Pfizer, one of the world’s largest pharmaceutical enterprises, has bought the makers of Emergen-C. The vitamin C supplement is filling out the Pfizer consumer product portfolio, according to my friend Tracy Staton, who reports for FiercePharma.

Pfizer is snapping up the company that makes Emergen-C, those ubiquitous vitamin C packets that sell for some $10 a box. The world’s biggest drugmaker will add California-based Alacer to its consumer health operations, acquired along with Wyeth in 2009. “Emergen-C products add to and greatly complement our market-leading dietary supplement portfolio,” Pfizer Consumer Healthcare President Paul Sturman said in a statement. Alacer makes about 500 million Emergen-C packets a year, Pfizer said. The terms of the deal weren’t disclosed.

Viral Times unfolds its story in a near-future where pharmas like Pfizer are allied with health insurance providers to create the PharmAlliance. This latest news shows Pfizer is expanding its business to include products like the 30-cent-a-day Emergen-C which don’t require medical insurance coverage, or a prescription, and so will never fall out of high-profit patent drug status. Patent drugs can have a very finite lifespan of profitability, while viruses have an infinite lifespan because they evolve as needed. The disease will usually outlast the drugs, if a virus is at work.

For example, Pfizer is struggling to maintain its client base for Lipitor this year, extending its own “co-pay” program to keep the brand-name version cheaper than the single generic version. Tracy reported in a separate article that WellPoint, a very large healthcare insurer, is now planning to stop covering Pfizer’s brand-name cholesterol drug April 1, favoring its generic rivals instead.

Tracy was an early workshopping reader of Viral Times before she took her MFA in writing from Texas State. She reports on pharmas for the Fierce group, as well as works as an associate editor for American Way magazine.

Written by Ron Seybold

February 28, 2012 at 4:28 pm

Bird flu goes airborne after modification

leave a comment »

20120108-182153.jpgA story in the New York Times reports that scientists are learning that avian flu has acquired airborne transmission ability after it was modified for increased strength. The experiments were part of studies to learn how the virus behaves. Now this virus can survive in the nose of ferrets, mammals whose nostril temperature is 4 degrees C cooler than a bird’s gut, where H5N1 usually grows.

The article points out that there’s a difference in ferret noses and those of us higher order mammals. One point cannot be smoothed out, however. The crossover point of animal to human is a step closer after this discovery. That kind of crossover is a prospect for triggering a pandemic.

Written by Ron Seybold

January 8, 2012 at 7:15 pm

Posted in Public health, Virus protection

Tagged with , , ,

Israeli pharma promises immunity boost drug

leave a comment »

Cancers are caused by viruses. (So many diseases start with a virus.) A new drug might be able to treat people who already have a cancer, by employing the body’s natural immunity T-cells to attack cancer cells. No mention in this link about availability of the drug, but since it’s developed outside the US, approval can be much swifter. You’d still need traditional chemo/surgery for advanced cancers. But this is a novel way to get a pharma solution to ally with natural immunity. If you can afford the booster shots.

This is the kind of medicine that the PharmAlliance wants to create in Viral Times. There is the US government in the way of approving that drug, in my future of 2021. But for now, here’s the early report on ImMucin.

A traditional vaccine helps the body’s immune system fend off foreign invaders such as bacteria or viruses, and is administered to people who have not yet had the ailment. Therapeutic vaccines, like the one Vaxil has developed, are given to sick people, and work more like a drug.

Vaxil’s lead product, ImMucin, activates the immune system by “training” T-cells –– the immune cells that protect the body by searching out and destroying cells that display a specific molecule (or marker) called MUC1. MUC1 is typically found only on cancer cells and not on healthy cells. The T-cells don’t attack any cells without MUC1, meaning there are no side effects unlike traditional cancer treatments. More than 90% of different cancers have MUC1 on their cells, which indicates the potential for this vaccine.

ImMucin is foreseen as a long-term strategy — a shot every few months, with no side effects — to stop the cancer from reoccurring after initial treatments, by ensuring that the patient’s own immune system keeps it under control.

Written by Ron Seybold

November 11, 2011 at 11:21 am

Posted in Public health, Vaccines, Virus protection

Tagged with ,

The future of naturopathic medicine

leave a comment »

Tabitha Parker

Utne Reader has posted an article about medicine that plays a major role in defense of viruses in my novel Viral Times. Dr. Tabatha Parker’s skill set is similar to Delta’s, as well as my co-protagonist Angie Consoli. They are naturopaths, 10 years into the future.

The global health care system is in crisis, says Dr. Tabatha Parker, founder of Natural Doctors International (NDI). It relies on the exportation of a Western model—one that doesn’t even work in the countries it’s coming from—to developing countries that can’t afford it.

Parker, a naturopathic doctor, sees NDI as a bridge between exported conventional medicine and centuries-old indigenous healing techniques, such as the use of herbal medicine, which in some places in the world is the dominant type of health care. “That has to be a part of the system if you’re going to actually reach people,” Parker says. Naturopathic doctors “are trained in a way that no one else in the world is trained: to be [that] bridge.”

Read more: http://www.utne.com/Mind-Body/Utne-Reader-Visionaries-Dr-Tabatha-Parker-Natural-Doctors-International.aspx#ixzz1dPVANRIL

Written by Ron Seybold

November 11, 2011 at 10:22 am

Follow

Get every new post delivered to your Inbox.