Ron Seybold's Viral Times

A story to inject hearts with insight, hope and health

Government funds hurry-up disease fighters

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The world is so far behind on its supply of anti-bacterial drugs that the US government is paying a major pharma to create and test formulas more quickly. This government aid to pharmaceutical giants like GlaxoSmithKline rolls into full tilt in Viral Times, just some five years from now.

But this year, pressure has mounted for accelerated creation of drugs to fight superbugs — things like MRSA and worse, for which there appears to be no protection. Going to the hospital is a serious decision itself about maintaining health.

From the New York Times:

Government officials, drug companies and medical experts, faced with outbreaks of antibiotic-resistant “superbugs,” are pushing to speed up the approval of new antibiotics, a move that is raising safety concerns among some critics.

The need for new antibiotics is so urgent, supporters of an overhaul say, that lengthy studies involving hundreds or thousands of patients should be waived in favor of directly testing such drugs in very sick patients. Influential lawmakers have said they are prepared to support legislation that allows for faster testing.

The Health and Human Services Department last month announced an agreement under which it will pay $40 million to a major drug maker, GlaxoSmithKline, to help it develop medications to combat antibiotic resistance and biological agents that terrorists might use. Under the plan, the federal government could give the drug company as much as $200 million over the next five years.

“We are facing a huge crisis worldwide not having an antibiotics pipeline,” said Dr. Janet Woodcock, director of the Center for Drug Evaluation and Research at the Food and Drug Administration. “It is bad now, and the infectious disease docs are frantic. But what is worse is the thought of where we will be five to 10 years from now.”

If you play out this trend, two aspects emerge. First, the defense of our populace from disease will make the military defense budgets look small. While you’re unlikely to be attacked by a rogue cell of terrorists, catching a superbug is a genuine possibility. Uncounted billions will be tossed at this threat.

Second, this is only drug defense against bacterial infection we’re seeing in the Times story. Viruses are much more adaptive and evasive. We have fewer successful anti-virals than anti-bacterials. It’s reasonable to imagine that pharmacos, like PharmaCorp in Viral Times, can grow larger than a defense contractor like McDonnell Douglas.

Written by Ron Seybold

July 5, 2013 at 3:47 pm

Ebola sneaks past immune system

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One of the world’s deadliest viruses uses sophisticated masking techniques to evade immunizations, according to Emory University. The university directly across the road from the Center for Disease Control and Prevention said in a study

Efforts to develop a vaccine against Ebola virus have met with limited success, and it is likely that the virus employs complex immune evasion mechanisms that present unique challenges for vaccine design. Understanding these evasion mechanisms is a critical first step in developing an effective vaccine.

Gopi Mohan, a graduate student at Emory University is first author of the paper. Richard Compans, professor of microbiology and immunology, led the research along with assistant professor Chinglai Yang.

In Viral Times, a New Flu weakens the bodies of loved ones enough to let them contract HIVE-5, the latest immune deficiency virus. Ebola is far more lethal, but it uses vectors of bats and pigs to travel to its hosts. HIVE-5, and the resulting AIDS Ultra, is transmitted by touch. It’s up to Dayton Winstead and Angie Consoli to discover how the most deadly virus survives and thrives, in order to stop its spread.

Written by Ron Seybold

December 25, 2012 at 9:25 pm

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West Nile Virus on the rise in Texas

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In my home here in Austin, we’re hearing reports about a rising number of infections from the West Nile Virus. The mosquito population here never carried this disease, at least not until this year. Now there’s been seven reported infections in the Austin area, and at least one death statewide. A few people in my family are scared.

What’s notable is that the warnings and reports include the word epidemic. One doctor said he’d never seen an epidemic like this in Texas. He’s relying on a definition of the word that people who’ve seen Contagion may not understand — but it’s not the right term. An epidemic is a series of infections which are high in number across a geographic area. The number of infections, in total, doesn’t create an epidemic. You need a concentrated geographic area.

He may have been using comparative thinking, but seven infections among a Texas population of more than 15 million — anybody who gets a mosquito bite could be infected — well, that’s not a high number. Not high enough for an epidemic. Under one definition, an epidemic has to spread quickly, too. An epidemic is in a concentrated geographic area. We’re hearing our reports about Travis County. But that’s only seven reports.

Our world endured an H1N1 pandemic over the past two years. That’s an infection across vast geographic areas, though not necessarily high in overall numbers. Despite that official UN health organization’s designation, the 2010-11 infections didn’t change the world’s physical contact between persons, or reshape laws about sanitation and disinfection. Or spark a tremendous business sector devoted to protection. That’s the stuff of Viral Times — although the governments of my novel are not responding evenly, or with enough resources.

Written by Ron Seybold

August 8, 2012 at 8:59 am

Climate changes will increase evolution of new flu strains

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A report from Duke University’s Nicholas School of the Environment says changing climate will affect the likelihood of contracting a new deadly strain of the flu. Never mind the heat — it’s the infection that will get you.

Migratory birds play a central role by giving a virus an additional opportunity to evolve

It’s the shifts between El Nino and La Nina weather that will wreak havoc with the bird migration patterns. Birds, migratory birds in particular, play a central role, by either passing a flu strain directly to humans (as in the case of H1N1) or indirectly via an intermediate host, giving the virus an additional opportunity to evolve.

The El Niño-La Niña oscillations cause significant changes in regional rainfall rates and wind patterns, which in turn affect the migration pattern of birds. And these shifts lead to different groups of of bird species coming into contact with each other in a given region, allowing for new strains of influenza to develop that eventually jump to humans.

In Viral Times, birds are an active transmission agent in the spread of the New Flu and other viruses. The dominant breeds of birds, especially starlings and crows, are among the deadliest of these agents.

The El Niño-Southern Oscillation (ENSO) refers to the state of the tropical Pacific Ocean as it sloshes back and forth, like water in a huge bathtub, west and east between Asia and the Americas. This movement affects temperatures and weather patterns worldwide.

One means to combat the infection might be to reduce use of fossil fuels. But after generations of burning coal and oil, it might be too late to reverse the Nino-Nina bathtub slosh effects. It’s back to our firewall of protection against viruses: natural immunity.

Written by Ron Seybold

May 2, 2012 at 4:44 pm

Ancient medicines you can grow or spin

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An article on the Slate website interviews a medical researcher whose specialty is discovering ancient remedies to diseases. One such remedy, broccoli, was so often prescribed that the Roman leader Cato advised all residents of the city to grow their own. In one instance it appears to have been used for colon cancer treatments.

Then there’s the spider webs.

In the world of Viral Times these are the remedies pursued, tested and used by naturopathic healers like Angie Consoli, the woman who finds the prospect of recovering love that she lost in the viral pandemics which sparked AIDS Ultra. Given the right cocktail of these healing arts, diseased people without medical plans sometimes survive without pharma medicine.

 

Written by Ron Seybold

March 6, 2012 at 3:18 pm

A Kindness Virus, and H5N1’s Flaws

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Viruses exhibit legendary behavior, especially in the power of their ability to spread. It’s one reason why something that spreads without any barriers is said to have “gone viral.” Now there’s a website that’s devoted to the concept of kindness spreading like a virus.

Good Virus has a 2-minute movie that leads you into a site that’s devoted to the mission of revealing kindness as an essential human element. We’re all infected with it.

The purpose of Good Virus is: 1) to illustrate that—contrary to what you may see, hear and read in the news—kindness is all around us (THE GOOD) and 2), to inspire people to spread that kindness (THE VIRUS). Good Virus is all about the small things, tiny acts of kindness that don’t cost a lot of money or oblige praise. The essential premise of this project is that many small acts of kindness may make more of a difference than a few big ones.

In Viral Times, one unstoppable defense against disease is love. Love breeds faith, and any faith in immunity raises the level of natural immune system defenses. A wide range of other healing arts are needed to survive a pandemic. But inducing kindness is simpler than raising the level of T-cells. Plus, the former can lead to the latter: meditation for example, shown to be an element in the increase of immunity.

If there’s a learning curve to spread the virus of kindness, nature compensates with a few barriers for disease viruses. There are natural flaws that a biological virus can exhibit in spreading. Scientists report that H1N1 doesn’t spread as effectively as a flu virus. From the journal Science we learn that aerosol transmission hasn’t been a feature of “bird flu,” the root of H5N1. Good thing.

A distinctive feature of avian influenza viruses in general, and H5N1 viruses in particular, is that they are incapable of being transmitted among humans by aerosol. Because pandemic influenza strains originated in avian influenza viruses, it can be argued that past pandemic influenza viruses were once avian influenza viruses that “learned” how to jump to and transmit by aerosol in humans.

The New Flu in Viral Times is a precursor to other disease. Nothing is more effective than the flu in propagating itself. Good Virus’s film states that scientists believe kindness spreads like a flu virus, however. So go spread a virus.

Written by Ron Seybold

March 5, 2012 at 3:22 pm

Pharma titan Pfizer adds natural immunity product

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Pfizer, one of the world’s largest pharmaceutical enterprises, has bought the makers of Emergen-C. The vitamin C supplement is filling out the Pfizer consumer product portfolio, according to my friend Tracy Staton, who reports for FiercePharma.

Pfizer is snapping up the company that makes Emergen-C, those ubiquitous vitamin C packets that sell for some $10 a box. The world’s biggest drugmaker will add California-based Alacer to its consumer health operations, acquired along with Wyeth in 2009. “Emergen-C products add to and greatly complement our market-leading dietary supplement portfolio,” Pfizer Consumer Healthcare President Paul Sturman said in a statement. Alacer makes about 500 million Emergen-C packets a year, Pfizer said. The terms of the deal weren’t disclosed.

Viral Times unfolds its story in a near-future where pharmas like Pfizer are allied with health insurance providers to create the PharmAlliance. This latest news shows Pfizer is expanding its business to include products like the 30-cent-a-day Emergen-C which don’t require medical insurance coverage, or a prescription, and so will never fall out of high-profit patent drug status. Patent drugs can have a very finite lifespan of profitability, while viruses have an infinite lifespan because they evolve as needed. The disease will usually outlast the drugs, if a virus is at work.

For example, Pfizer is struggling to maintain its client base for Lipitor this year, extending its own “co-pay” program to keep the brand-name version cheaper than the single generic version. Tracy reported in a separate article that WellPoint, a very large healthcare insurer, is now planning to stop covering Pfizer’s brand-name cholesterol drug April 1, favoring its generic rivals instead.

Tracy was an early workshopping reader of Viral Times before she took her MFA in writing from Texas State. She reports on pharmas for the Fierce group, as well as works as an associate editor for American Way magazine.

Written by Ron Seybold

February 28, 2012 at 4:28 pm

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